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Whereas very low-count MBL not often progresses to CLL, high-rely MBL progresses to CLL demanding therapy at a amount of one% to 2% a year. Substantial-rely MBL is distinguished from Rai 0 CLL depending on whether the B-mobile depend is over or beneath five × 109/L. Whilst individuals with both significant-count MBL and CLL Rai stage 0 are at increased possibility of bacterial infections and second cancers, the risk of development requiring therapy and the likely to shorten existence expectancy are greater for CLL. This review highlights demanding queries regarding the classification, risk stratification, management, and supportive treatment of patients with MBL and CLL.

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mutations and sophisticated kar yotype. It follows a linear evolution with the CLL clone throughout the recurrent acquisition of CDKN2A

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